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	<title>Multitarget equation - Revision history</title>
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	<updated>2026-04-30T01:17:20Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>http://icrpaedia.org/index.php?title=Multitarget_equation&amp;diff=3019&amp;oldid=prev</id>
		<title>Chris Clement: Created page with &quot;link=ICRP Glossary Model that assumes the presence of a number of critical targets in a cell, all of which require inactivat...&quot;</title>
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		<updated>2021-08-12T17:37:22Z</updated>

		<summary type="html">&lt;p&gt;Created page with &amp;quot;&lt;a href=&quot;/File:Glossary_Icon-2.png&quot; title=&quot;File:Glossary Icon-2.png&quot;&gt;100px|frameless|right|link=ICRP Glossary&lt;/a&gt; Model that assumes the presence of a number of critical targets in a cell, all of which require inactivat...&amp;quot;&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;[[File:Glossary Icon-2.png|100px|frameless|right|link=ICRP Glossary]]&lt;br /&gt;
Model that assumes the presence of a number of critical targets in a cell, all of which require inactivation to kill the cell. Surviving fraction of a cell population is given by the formula:&lt;br /&gt;
&lt;br /&gt;
&amp;lt;math&amp;gt;&lt;br /&gt;
P(x) = S = 1 - (1 - e^{{-xD}})^n&lt;br /&gt;
&amp;lt;/math&amp;gt;,&lt;br /&gt;
 &lt;br /&gt;
where S = probability of survival, D = a dose that causes a mean of one-hit per cell (mean lethal dose), x = number of hits per cell, and n = number of targets (required number of hits for cell death). (Adopted from Little JB. Cellular effects of ionizing radiation. N Engl J Med. 1968;278:369–76)&lt;br /&gt;
&lt;br /&gt;
(([[ICRP Publication 118]], 2012)&lt;br /&gt;
&lt;br /&gt;
'''Return to [[ICRP Glossary|Glossary]]'''&lt;/div&gt;</summary>
		<author><name>Chris Clement</name></author>
		
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